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This study models and investigates whether temporally interfering electric fields (TI EFs) could function as an effective non-invasive brain stimulation (NIBS) method for deep brain structure targeting in humans, relevant for psychiatric applications. Here, electric fields off- and on-target are modelled and compared with other common NIBS modalities (tACS, TMS). Additionally, local effects of the field strength are modelled on single-compartment neuronal models. While TI EFs are able to effectively reach deep brain targets, the ratio of off- to on-target stimulation remains high and comparable to other NIBS and may result in off-target neural blocks. Clinical Relevance- This study builds on earlier work and demonstrates some of the challenges -such as off-target conduction blocks- of applying TI EFs for targeting deep brain structures important in understanding the potential of treating neuropsychiatric conditions in the future.

Original publication

DOI

10.1109/embc48229.2022.9871476

Type

Journal article

Journal

Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference

Publication Date

01/07/2022

Volume

2022

Pages

1715 - 1718

Keywords

Brain, Cytoskeleton, Electricity, Epidemiological Models, Humans, Stereotaxic Techniques