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Corticotropin stimulation tests were used to assess adrenocortical function in 32 patients with septic shock. 13 patients had a poor cortisol response (rise less than 250 nmol/l) to corticotropin, all of whom died. However, there were only 6 deaths among the 19 patients with adequate responses (p less than 0.001). These results suggest that some patients with septic shock may have relative adrenocortical insufficiency.

Original publication

DOI

10.1016/0140-6736(91)91641-7

Type

Journal article

Journal

Lancet (London, England)

Publication Date

03/1991

Volume

337

Pages

582 - 583

Addresses

Intensive Therapy Unit, South Cleveland Hospital, Middlesbrough, UK.

Keywords

Humans, Shock, Septic, Hydrocortisone, Prognosis, Stimulation, Chemical, Time Factors, Adult, Aged, Aged, 80 and over, Middle Aged, Female, Male, Adrenocorticotropic Hormone, Evaluation Studies as Topic