Contact information
Research groups
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Kate Attfield
Principal Investigator
Physical and mental disability caused by neuroinflammation is a common clinical occurrence in many diseases, including multiple sclerosis (MS), Alzheimer’s disease and schizophrenia. However, the cause(s) of this inflammation and the devastating consequences that ensue are poorly defined, as reflected by a lack of effective treatments.
As demonstrated by our previous work, with a particular focus on multiple sclerosis, we have shown how studying individual cells directly from patient blood or mapping biological events across the diseased brain in post-mortem tissue, can expose an intricate network of neuroinflammatory processes, which change through time and space. With evolving technologies, our research team seeks to understand how the immune system and resident cells of the central nervous system orchestrate these disease processes.
Recent publications
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Antibody agonists trigger immune receptor signaling through local exclusion of receptor-type protein tyrosine phosphatases
Journal article
Lippert AH. et al, (2024), Immunity
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The immunology of multiple sclerosis.
Journal article
Attfield KE. et al, (2022), Nat Rev Immunol
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Identifying CNS-colonizing T cells as potential therapeutic targets to prevent progression of multiple sclerosis
Journal article
Kaufmann M. et al, (2021), Med, 2, 296 - 312.e8
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Recovery from COVID-19 in a B-cell-depleted multiple sclerosis patient
Journal article
Wurm H. et al, (2020), Multiple Sclerosis Journal, 26, 1261 - 1264
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A novel neurodegenerative spectrum disorder in patients with MLKL deficiency.
Journal article
Faergeman SL. et al, (2020), Cell Death Dis, 11