Search results
Found 18719 matches for
-
The spatial correspondence and genetic influence of inter-hemispheric connectivity with white matter microstructure
6 February 2019
<jats:p>Microscopic features (i.e., microstructure) of axons affect neural circuit activity through characteristics such as conduction speed. Deeper understanding of structure-function relationships and translating this into human neuroscience has been limited by the paucity of studies relating axonal microstructure in white matter pathways to functional connectivity (synchrony) between macroscopic brain regions. Using magnetic resonance imaging data in 11354 subjects, we constructed multi-variate models that predict the functional connectivity of pairs of brain regions from the microstructural signature of white matter pathways that connect them. Microstructure-derived models provide predictions of functional connectivity that were significant in up to 86% of the brain region pairs considered. These relationships are specific to the relevant white matter pathway and have high reproducibility. The microstructure-function relationships are associated to genetic variants (single-nucleotide polymorphisms), co-located with genes DAAM1 and LPAR1, that have previously been reported to play a role in neural development. Our results demonstrate that variation in white matter microstructure across individuals consistently and specifically predicts functional connectivity, and that this relationship is underpinned by genetic variability.</jats:p>
-
Bullying Victimisation and Risk of Psychotic Phenomena
15 October 2018
-
Extending the Human Connectome Project across ages: Imaging protocols for the Lifespan Development and Aging projects.
7 November 2018
The Human Connectome Projects in Development (HCP-D) and Aging (HCP-A) are two large-scale brain imaging studies that will extend the recently completed HCP Young-Adult (HCP-YA) project to nearly the full lifespan, collecting structural, resting-state fMRI, task-fMRI, diffusion, and perfusion MRI in participants from 5 to 100+ years of age. HCP-D is enrolling 1300+ healthy children, adolescents, and young adults (ages 5-21), and HCP-A is enrolling 1200+ healthy adults (ages 36-100+), with each study collecting longitudinal data in a subset of individuals at particular age ranges. The imaging protocols of the HCP-D and HCP-A studies are very similar, differing primarily in the selection of different task-fMRI paradigms. We strove to harmonize the imaging protocol to the greatest extent feasible with the completed HCP-YA (1200+ participants, aged 22-35), but some imaging-related changes were motivated or necessitated by hardware changes, the need to reduce the total amount of scanning per participant, and/or the additional challenges of working with young and elderly populations. Here, we provide an overview of the common HCP-D/A imaging protocol including data and rationales for protocol decisions and changes relative to HCP-YA. The result will be a large, rich, multi-modal, and freely available set of consistently acquired data for use by the scientific community to investigate and define normative developmental and aging related changes in the healthy human brain.
-
Myelin oligodendrocyte glycoprotein (MOG) antibody-associated disease: practical considerations.
17 December 2018
The field of central nervous system (CNS) inflammatory diseases has recently broadened to include a new condition associated with pathogenic serum antibodies against myelin oligodendrocyte glycoprotein (MOG). This is distinct from multiple sclerosis (MS) and aquaporin-4 (AQP4) antibody neuromyelitis optica spectrum disorders (NMOSD). MOG antibody-associated disease phenotypes are varied and range from classical neuromyelitis optica to acute demyelinating encephalomyelitis and cortical encephalitis. The diagnosis depends on using a reliable, specific and sensitive assay of the antibody. Clinical and imaging features of MOG-associated syndromes overlap with AQP4 antibody NMOSD but can be usually distinguished from MS: in particular, the silent lesions typical of MS that progressively increase lesion volume are rare in MOG antibody disease. The disease can relapse but medium-term immunosuppression appears to be protective. Permanent disability, particularly severe ambulatory and visual disability, is less frequent than in AQP4 antibody NMOSD and usually results from the onset attack. However, sphincter and sexual dysfunction after a transverse myelitis is common. Here we review the practical aspects of diagnosing and managing a patient with MOG antibody-associated disease.
-
Samiha Shaikh
8 May 2018
-
PiNG representation at OHBM 2017
29 June 2017
Posters and talks from PiNG Members at the 2017 OHBM meeting in Vancouver, Canada
-
REFLECT publications
28 January 2019
-
Published Paper: Clinical EEG and Neuroscience
14 November 2017
"High-Intensity Chronic Stroke Motor Imagery Neurofeedback Training at Home: Three Case Reports" - Zich et al. 2017
-
Alumni
16 July 2018
-
Collaborations
17 July 2018
-
June 2017
13 July 2017
Rebecca Pullon has recently completed her DPhil with the Department of Engineering. Her thesis focused on the development of an early warning scoring system during pregnancy, working on data from the 4P Project, funded by the Oxford NIHR Biomedical Research Centre. Here she writes about the challenges of designing an obstetric early warning score system.
-
Brain stimulation & neuroimaging
10 June 2015
-
Adam Steel wins NIH/OxCam Innovation Award
29 June 2017
Adam wins award for his work developing Magnetic Resonance Spectroscopic Imaging (MRSI) with Charlie Stagg and Uzay Emir
-
Natural Killer cells used to treat chronic pain
1 February 2019
Damage to nerves during surgery or after an injury can lead to long-term pain. Scientists have found that specialised cells help to remove damaged nerve fibres, allowing new healthy nerves to re-grow, ameliorating nerve pain.
-
Young people get a taste of working in our labs
3 September 2018
Four students were placed in our department as part of the In2Science programme this summer.
-
First human test of robotic eye surgery a success
18 June 2018
The first trial of robot-assisted eye surgery in patients has shown the technique to be both safe and effective.
-
NDCN research underpins new European licence for migraine prevention drug
31 July 2018
Novartis receives European licence for Aimovig® (erenumab), the first treatment designed specifically for the prevention of migraine
-
Brain scanning and breathing disorders
20 September 2017
Anaesthetics Integrative Neuroimaging Research
Professor Kyle Pattinson from the Nuffield Department of Clinical Neurosciences explains how brain scanning could help doctors to personalise treatment for people with chronic breathing disorders.
-
World’s largest autism grant will transform research landscape
26 October 2018
The largest research grant ever given for neurodevelopmental conditions has been awarded by the Innovative Medicines Initiative to an international consortium academically led by the Institute of Psychiatry, Psychology & Neuroscience (IoPPN) at King’s College London.
-
A new approach to improving hemispatial neglect after stroke
3 October 2017
Integrative Neuroimaging Research
Research by Jacinta O’Shea reveals the striking potential of brain stimulation to cause long-lasting improvements in stroke patients’ attention deficits.
-
Students from around the world find out about our research
10 August 2016
Students pursuing a career in science and medicine visited our department on 4 August
-
Research Projects
26 January 2018
-
Current Research Projects
10 June 2015
-
Future Developments
4 December 2015
-
FSL Tools
5 December 2015
-
Current Research
10 June 2015
-
Research Studies
4 August 2017
-
Funding Sources
11 February 2016
-
Research Projects
13 September 2017
-
Public Engagement
15 July 2016
Reports and adverts of where and when members of the Physiological Neuroimaging Group have been involved in public engagement events
-
CALMS research study
For more information about the CALMS study, please visit the Oxford Biomedical Research Centre website
-
Oxford 4P research study
For more information about the 4P research study, please visit the Oxford Biomedical Research Centre website
-
OTEST research study
For more information about the OTEST research study please visit the Oxford Biomedical Research Centre website
-
“Unexpected ways to wake up your brain”
BBC News – 30th October 2014
-
“Michael Mosley has an electric current put through his brain”
Trust Me I’m A Doctor (BBC Two) - October 2014
-
Oxford Subarachnoid Haemorrhage Research Group
6 June 2017
Our group aims to achieve a better understanding of what happens in the brains of patients who have just had a subarachnoid haemorrhage, which is a type of stroke.
-
Experimental and Clinical Sleep Medicine
22 February 2018
Professor Colin Espie is the Director, and Dr. Simon Kyle the Deputy Director, of the Experimental and Clinical Sleep Medicine group with the Sleep and Circadian Neuroscience Institute, University of Oxford. We conduct human experimental and clinical studies on sleep and disorders of sleep with the aim of understanding their pathophysiology and in the mechanisms of action of treatments. Our research is supported by numerous national and international funders, including the Wellcome Trust, NIHR, Swiss National Science Foundation, Education Endowment Fund, and the Dr. Mortimer and Theresa Sackler Foundation, amongst others.
-
Action, Cognition & Neurotherapeutics
10 June 2015
We aim to understand processes of selective attention and action, learning and memory in the human brain. Through experiments in healthy volunteers and patients with brain disorders we seek to characterize how information processing networks respond (adaptively or maladaptively) when challenged by interference. Our motivation is to develop rational neurocognitive intervention strategies to help promote recovery from conditions such as depression and brain injury.
-
pain & mind
11 August 2016
Beliefs shape our perception of pain. Using non-invasive magnetic resonance imaging in humans, we investigate how beliefs are generated, maintained and revised in the brain and how they influence pain perception.
-
Diagnostic and Advisory Service for Neuromyelitis Optica
15 January 2013
Neuromyelitis optica (NMO) is a rare disease causing inflammation in the spinal cord and optic nerves. The NMO service brings together expertise in diagnostics and clinical management to improve outcomes for this often isolated group of patients.
-
Autoimmune Neurology Group
18 June 2014
Research, diagnostic and testing service of autoantibodies associated with neurological diseases.
-
Oxford Centre for Neuroinflammation
22 February 2018
We bring together biomedical, analytical and clinical expertise to shed new light on the causes that underpin neurodegenerative diseases.
-
WIN Neuroplastics network
15 January 2013
Neuroplastics is a collaborative network of three research groups at WIN with a shared interest in brain plasticity. We study how the brain changes when we learn, as we get older, or when we recover from damage such as stroke. We use brain imaging to monitor brain change and we aim to develop new approaches to facilitate learning, recovery and healthy ageing.
-
Overview
4 December 2018
-
How to apply
4 December 2018
-
Potential Projects 2019-20
4 December 2018
-
Courses
19 October 2012
-
Anaesthesia in Developing Countries
4 March 2013
Five day International Course, Uganda. The next course is expected to run in November 2019. Please email events@ndcn.ox.ac.uk if you would like to be notified when we open for booking.
-
Global Surgery
27 March 2018
This five-day course looks at the provision of surgical services at a global level, encompassing all related specialties including obstetrics, gynaecology and anaesthesia/critical care.
-
Oxford Neurology Course
4 March 2013
-
Oxford Autoimmune Neurology Meeting 2019
28 November 2018
This is a two-day international meeting on 5-6 June 2019 for clinicians and scientists looking to appreciate the breadth of translational autoimmune neurology.
-
Graduate Administration Team
4 December 2018
-
Funding
4 December 2018
-
Neuropathology
15 January 2013
Neuropathology is at the interface of clinical and basic neurosciences.
-
Event types
4 November 2017