Pain, as we know, is highly personal. Some can cope with huge amounts, while others reel in agony over a seemingly minor injury. Though you might feel the stab of pain in your stubbed toe or sprained ankle, it is actually processed in the brain.
That is where Irene Tracey, Nuffield Professor of Anaesthetic Science at Oxford University, has been focussing her attention. Known as the Queen of Pain, she has spent the past two decades unravelling the complexities of this puzzling sensation.
She goes behind the scenes, as it were, of what happens when we feel pain - scanning the brains of her research subjects while subjecting them to a fair amount of burning, prodding and poking.
Her work is transforming our understanding, revealing how our emotions influence our experience of pain, how chronic pain develops and even when consciousness is present in the brain.