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New study shows clinical symptoms for Alzheimer’s can be predicted in preclinical models

Clinical Neurology Research

Establishing preclinical models of Alzheimer’s that reflect in-life clinical symptoms of each individual is a critically important goal, yet so far it has not been fully realised. A new collaborative study from the University of Oxford has demonstrated that clinical vulnerability to an abnormally abundant protein in Alzheimer’s brain is in fact reflected in individual patient induced pluripotent stem cell-derived cortical neurons.

MSc Clinical and Therapeutic Neuroscience: Class 2021/22 Prizes

Award

Congratulations to our MSc in Clinical and Therapeutic Neuroscience, Class of 2021/22 for successfully completing the course.

Visit from the Sir Jules Thorn Charitable Trust

Ophthalmology Research

Earlier this month, we were delighted to welcome the Director of the Sir Jules Thorn Charitable Trust, Richard Benson, and its Chair of Trustees, Liz Charal.

Oxford receives £122m funding for healthcare research

Award Research

Health and care research in Oxford is to receive £122 million in government funding over the next five years to improve diagnosis, treatment and care for NHS patients. Our department will play a major role.

New insights gained into how the brain encodes information about the world

Clinical Neurology Research

Scientists have developed a new way to test the theory that active neurons can change what they signal in the world, rather than keeping a stable correspondence to things (such as a features of an object, or ideas).

Oxford and Quinnipiac researchers discuss integrated clinical care, education, and research in multiple sclerosis

Clinical Neurology Research Teaching

Mount Sinai Rehabilitation Hospital's Mandell Center for Multiple Sclerosis Care and Neuroscience Research welcomed University of Oxford partners in September. Stakeholders from University of Oxford and Quinnipiac University met to discuss ongoing research and future opportunities to develop a Mandell MS Center concept of care in the UK.

Royal Academy of Engineering Research Fellowship

Award Integrative Neuroimaging Research

Dr Rezvan Farahibozorg has received one of 17 Royal Academy of Engineering Research Fellowships for 2022.

Three New Professors

Research

Many congratulations to the following members of our Department who have been awarded the title of Professor in the recent Recognition of Distinction round.

Repurposed drug could help patients with motor neuron disease

Clinical Neurology Research

A drug typically used to treat enlarged prostates and high blood pressure has shown promise as a potential new therapy for motor neuron disease (MND), according to a new study.

Finding out more about Parkinson’s by monitoring symptoms at home

Clinical Neurology Research

Professor Chrystalina Antoniades explains how the COVID pandemic accelerated an innovation in one research project into Parkinson's Disease.

Discovery of gene involved in chronic pain creates new treatment target

Clinical Neurology Research

Our researchers have discovered a gene that regulates pain sensitisation by amplifying pain signals within the spinal cord. This is helping them to understand an important mechanism underlying chronic pain in humans, and provides a new treatment target.

Lymph nodes reveal more about mechanisms of autoimmunity

Clinical Neurology Research

Two recent papers show that studying lymph nodes reveals details of the mechanisms of autoimmunity.

Multiple heart-related conditions linked to triple dementia risk, regardless of genetics

Clinical Neurology Research

Having multiple conditions that affect the heart is linked to a greater risk of dementia than having high genetic risk, according to a large-scale new study.

NDCN research presented at Myasthenia Gravis conference

Clinical Neurology Research

The 14th Quinquennial Myasthenia Gravis Federation of America International Conference was recently held in Miami with 450 delegates attending in person, including over 100 from industry.

Magnetic signatures of the brain characterised in UK Biobank imaging study

Integrative Neuroimaging Research

A study published this week in Nature Neuroscience demonstrates how studying the magnetic properties of tissue may provide a unique window into brain health and disease.

NICE recommends offering app-based treatment for people with insomnia instead of sleeping pills

Ophthalmology Research

Hundreds of thousands of people suffering from insomnia who would usually be prescribed sleeping pills could be offered an app-based treatment programme instead, NICE has said.

Developmental dynamics of the neural crest–mesenchymal axis in creating the thymic microenvironment

Clinical Neurology Research

A new paper from researchers at the Department of Paediatrics and the Nuffield Department of Clinical Neurosciences has shown that fibroblasts in the thymus, often considered simply as dull “structural” cells, are much more complex than previously thought.

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