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We have compared the onsets of expression of the classical visual opsins with those of the non-rod, non-cone opsins in foetal and post-natal eye tissue from mice and humans. Mouse Rgr-opsin, peropsin, encephalopsin and melanopsin are all expressed in foetal development by E11.5, unlike the murine rod and cone opsins that exhibit post-natal expression, e.g. P1 for ultraviolet cone opsin and P5 for rod opsin. Human non-rod, non-cone opsins are also all expressed early, by 8.6 weeks post-conception. The implications of these observations are discussed with regard to the possible functions of these opsins at early stages of ocular development.

Type

Journal article

Journal

Exp Eye Res

Publication Date

03/2003

Volume

76

Pages

393 - 396

Keywords

Animals, Embryonic and Fetal Development, Eye, Gene Expression Regulation, Developmental, Humans, Mice, Reverse Transcriptase Polymerase Chain Reaction, Rod Opsins