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The discovery of the complement factor H (CFH) polymorphism in age-related macular degeneration (AMD) strongly suggests a causative role of the complement system in the pathogenesis of this disease. The complement system is part of the innate immune system and is closely associated with the cellular response and the adaptive immune system. This article provides an overview of the complement system and, taking the new data into account, of possible immunopathogenetic processes in AMD.

Original publication

DOI

10.1007/s00347-005-1269-4

Type

Journal article

Journal

Ophthalmologe

Publication Date

11/2005

Volume

102

Pages

1036 - 1042

Keywords

Bruch Membrane, Complement Factor H, Humans, Macular Degeneration, Models, Immunological, Pigment Epithelium of Eye