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The current study examined group differences in cortical volume, surface area, and thickness with age, in a group of typically developing children and a group of children with ASD aged 6-15 years. Results showed evidence of age by group interactions, suggesting atypicalities in the relation between these measures and age in the ASD group. Additional vertex-based analyses of cortical thickness revealed that specific regions in the left inferior frontal gyrus (BA 44) and left precuneus showed thicker cortex for the ASD group at younger ages only. These data support the hypothesis of an abnormal developmental trajectory of the cortex in ASD, which could have profound effects on other aspects of neural development in children with ASD.

Original publication

DOI

10.1007/s10803-011-1261-6

Type

Journal article

Journal

J Autism Dev Disord

Publication Date

03/2012

Volume

42

Pages

419 - 427

Keywords

Adolescent, Cerebral Cortex, Child, Child Development Disorders, Pervasive, Humans, Male, Nerve Fibers, Unmyelinated, Organ Size