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The laboratory mouse, with its genetic similarity to humans and rich set of tools for manipulating its genome, has emerged as one of the key models for experimental investigation of the genotype/phenotype relationships in mammals. Recent innovations have made MRI an increasingly popular tool for examining the phenotype of genetically altered mice. Advances in field strengths, mouse handling, image analysis and statistics have contributed greatly in this regard. In this chapter, we illustrate the methods necessary to achieve high-throughput phenotyping of genetically altered mice using multiple-mouse MRI combined with advanced image analysis techniques and statistics.

Original publication

DOI

10.1007/978-1-61737-992-5_17

Type

Journal article

Journal

Methods Mol Biol

Publication Date

2011

Volume

711

Pages

349 - 361

Keywords

Animals, Image Interpretation, Computer-Assisted, Magnetic Resonance Imaging, Mice, Mice, Transgenic, Nonlinear Dynamics, Phenotype