Excitatory GABAergic signalling is associated with benzodiazepine resistance in status epilepticus
Burman RJ., Selfe JS., Lee JH., van den Berg M., Calin A., Codadu NK., Wright R., Newey SE., Parrish RR., Katz AA., Wilmshurst JM., Akerman CJ., Trevelyan AJ., Raimondo JV.
<jats:p>Benzodiazepine-resistant status epilepticus is an ongoing clinical challenge. Burman et al. show that longer seizure duration is a useful clinical indicator of benzodiazepine resistance, and that resistance is caused by changes in GABAA receptor-mediated synaptic transmission. The findings could help optimise current management protocols.</jats:p>