Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings.

Since the development of cellular and myelin stains, anatomy has formed the foundation for understanding circuitry in the human brain. However, recent functional and structural studies using magnetic resonance imaging have taken the lead in this endeavor. These innovative and noninvasive approaches have the advantage of studying connectivity patterns under different conditions directly in the human brain. They demonstrate dynamic and structural changes within and across networks linked to normal function and to a wide range of psychiatric illnesses. However, these indirect methods are unable to link networks to the hardwiring that underlies them. In contrast, anatomic invasive experimental studies can. Following a brief review of prefrontal cortical, anterior cingulate, and striatal connections and the different methodologies used, this article discusses how data from anatomic studies can help inform how hardwired connections are linked to the functional and structural networks identified in imaging studies.

Original publication

DOI

10.1016/j.biopsych.2019.10.024

Type

Journal article

Journal

Biol Psychiatry

Publication Date

15/02/2020

Volume

87

Pages

318 - 327

Keywords

Anterior cingulate cortex, Connectivity, Diffusion magnetic resonance imaging, Hubs, Prefrontal cortex, Resting-state magnetic resonance imaging, Striatum, Tract-tracing experiments