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Effective T cell responses against infections and tumors require a swift and ample production of cytokines, chemokines, and cytotoxic molecules. The production of these effector molecules relies on rapid changes of gene expression, determined by cell-intrinsic signals and environmental cues. Here, we review our current understanding of gene-specific regulatory networks that define the magnitude and timing of cytokine production in CD8+ T cells. We discuss the dynamic features of post-transcriptional control during CD8+ T cell homeostasis and activation, and focus on the crosstalk between cell signaling and RNA-binding proteins. Elucidating gene-specific regulatory circuits may help in the future to rectify dysfunctional T cell responses.

Original publication

DOI

10.1016/j.it.2020.01.001

Type

Journal article

Journal

Trends in immunology

Publication Date

03/2020

Volume

41

Pages

240 - 254

Addresses

Laboratory of Lymphocyte Signalling and Development, The Babraham Institute, Cambridge, UK. Electronic address: fiamma.salerno@babraham.ac.uk.