Absence of Neuronal Autoantibodies in Neuropsychiatric Systemic Lupus Erythematosus.

Varley JA., Andersson M., Grant E., Berretta A., Zandi MS., Bondet V., Duffy D., Hunt D., Piehl F., Waters P., Irani SR.

This study aimed to characterise both neuronal autoantibodies and levels of interferon α, two proposed causative agents in neuropsychiatric systemic lupus erythematosus (NPSLE). Cerebrospinal fluid (CSF) and plasma from 35 patients with systemic lupus erythematosus (SLE; 15 with NPSLE) showed no antibodies against natively expressed N-methyl-D-aspartate receptors (NMDARs), or the surface of live hippocampal neurons. By comparison to controls (n = 104), patients with SLE had antibodies that bound to a peptide representing the extracellular domain of NMDARs (p

DOI

10.1002/ana.25908

Type

Journal article

Journal

Ann Neurol

Publication Date

12/2020

Volume

88

Pages

1244 - 1250

Keywords

Adolescent, Adult, Aged, Autoantibodies, Case-Control Studies, Cells, Cultured, Female, Hippocampus, Humans, Interferon-alpha, Lupus Vasculitis, Central Nervous System, Male, Middle Aged, Neurons, Receptors, N-Methyl-D-Aspartate, Young Adult

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