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PURPOSE: To exploit diffusion imaging tractography to produce a two-dimensional (xy) probabilistic population map of the cortical connections within the human internal capsule (IC). MATERIALS AND METHODS: Diffusion tensor imaging (DTI) was carried out on 11 healthy volunteers. We parceled an axial section of the IC according to its connections to the prefrontal, premotor, primary motor, primary somatosensory, posterior parietal, and occipital cortices using our locally developed probabilistic algorithm. RESULTS: A consistent topographical organization was generated that was consistent with our anatomical knowledge of the IC. In addition, our study shows that in humans the anterior half of the IC is occupied by the prefrontal cortex. CONCLUSION: This map may be of clinical use for correlating neurological deficit with hemispheric lesions, particularly those that affect sensorimotor function.

Original publication

DOI

10.1002/jmri.20810

Type

Journal article

Journal

J Magn Reson Imaging

Publication Date

01/2007

Volume

25

Pages

48 - 54

Keywords

Adult, Algorithms, Brain Mapping, Diffusion Magnetic Resonance Imaging, Echo-Planar Imaging, Female, Humans, Image Processing, Computer-Assisted, Internal Capsule, Male, Middle Aged, Reproducibility of Results