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Excessive synchronisation of basal ganglia activity at frequencies < 30 Hz is a hallmark of the parkinsonian state, and may contribute to bradykinesia. Accordingly, we electrically stimulated chronically implanted subthalamic macroelectrodes in 10 Parkinson's disease patients, after overnight withdrawal of anti-parkinsonian medication. We compared the effects of stimulation at 0, 5, 10, 15, 20, 25, 30, and ca. 130 Hz by measuring kinesia time (KT) in a tapping task. Although the effects of direct stimulation were small, frequency-response curves demonstrated local peaks at 5-10 Hz and at 20-25 Hz, superimposed upon an overall tendency for KT to reduce with increasing stimulation frequency. This is consistent with the hypothesis that spontaneous activities in these bands might promote bradykinesia.

Original publication

DOI

10.1016/j.neulet.2005.02.050

Type

Journal article

Journal

Neurosci Lett

Publication Date

01/07/2005

Volume

382

Pages

5 - 9

Keywords

Aged, Antiparkinson Agents, Beta Rhythm, Deep Brain Stimulation, Electrodes, Implanted, Female, Humans, Hypokinesia, Linear Models, Male, Middle Aged, Nonlinear Dynamics, Parkinson Disease, Psychomotor Performance, Subthalamic Nucleus