Reduced neurovascular coupling is associated with increased cardiovascular risk without established cerebrovascular disease: A cross-sectional analysis in UK biobank.

Yang S., Webb AJS.

Mid-life vascular risk factors predict late-life cerebrovascular diseases and poor global brain health. Although endothelial dysfunction is hypothesized to contribute to this process, evidence of impaired neurovascular function in early stages remains limited. In this cross-sectional study of 31,934 middle-aged individuals from UK Biobank without established cerebrovascular disease, the overall 10-year risk of cardiovascular events was associated with reduced neurovascular coupling (p 

DOI

10.1177/0271678X241302172

Type

Journal article

Journal

J Cereb Blood Flow Metab

Publication Date

22/11/2024

Keywords

Cerebral small vessel disease, endothelial function, hypertension, neurovascular coupling, vascular risk factors

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