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Neuroprotection can be applied to treatments that have a primary role in protecting nerves and axons from damage. Alternatively it can refer to treatments which act up-stream on the primary pathology and which have a secondary neuroprotective effect. Although there are many potential neuroprotective agents, clinical evidence to prove their hypothetical action is lacking. Studying natural brain repair processes is important in understanding how repair and recovery a) is limited in disease and can b) contribute to the development of treatments to enhance this process. Different mechanisms underlie repair and recovery and they vary in the time taken to produce improvement and the degree of translation into a clinical effect. Additionally individuals may vary in their ability to repair and this may contribute to the heterogeneity of diseases such as MS.

Original publication

DOI

10.1016/j.jns.2007.08.039

Type

Journal article

Journal

J Neurol Sci

Publication Date

15/02/2008

Volume

265

Pages

21 - 25

Keywords

Adrenal Cortex Hormones, Animals, Humans, Multiple Sclerosis, Neuroprotective Agents, Riluzole, Wound Healing