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Opsoclonus-myoclonus syndrome or Dancing Eye Syndrome (OMS/DES) is a rare neurological disorder of children, which associates with neuroblastoma (NB) in approximately 50% of cases. We examined sera from five patients with (OMS-NB(+)) and five without NB (OMS-NB(-)) for autoantibodies. OMS-NB(-) IgG bound to the surface of a NB cell line, whereas IgG from OMS-NB(+) and from NB patients without OMS/DES bound only to permeabilised cells. Both OMS-NB(+) and OMS-NB(-) reduced proliferation of NB cells. We also present a case report of a child with OMS/DES without NB who made a complete recovery without treatment. Serum antibodies at presentation bound to the surface and decreased NB cell proliferation but had decreased 9 weeks later when the child was asymptomatic. These results demonstrate that sera from some OMS/DES patients contain IgG antibodies that are potentially pathogenic.

Original publication

DOI

10.1016/j.jneuroim.2008.05.033

Type

Journal article

Journal

J Neuroimmunol

Publication Date

15/09/2008

Volume

201-202

Pages

221 - 226

Keywords

Analysis of Variance, Animals, Autoantibodies, Calcium Channels, Cell Line, Cell Proliferation, Cerebellum, Child, Preschool, Female, Flow Cytometry, Glutamate Decarboxylase, Humans, Infant, Male, Neuroblastoma, Opsoclonus-Myoclonus Syndrome, Potassium Channels, Protein Binding, Radioimmunoassay, Rats, Tetrazoles, Time Factors