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A 15-year-old girl, previously treated with radiation, chemotherapy, and surgery for a posterior fossa medulloblastoma and parasellar metastasis at age 8, presented with a 10-month history of episodic horizontal diplopia. She was diagnosed with ocular neuromyotonia and successfully treated with oral carbamazepine. Given the strong association between peripheral neuromyotonia and the presence of autoimmune antivoltage-gated potassium channels, the patient's blood was tested and found negative for these autoantibodies. This is the first time this has been verified in a person with ocular neuromyotonia.

Original publication

DOI

10.1016/j.jaapos.2008.05.011

Type

Journal article

Journal

J AAPOS

Publication Date

12/2008

Volume

12

Pages

616 - 617

Keywords

Adolescent, Autoantibodies, Carbamazepine, Cerebellar Neoplasms, Combined Modality Therapy, Cranial Fossa, Posterior, Female, Follow-Up Studies, Humans, Isaacs Syndrome, Medulloblastoma, Ocular Motility Disorders, Pituitary Neoplasms, Potassium Channels, Voltage-Gated, Radiation Injuries, Sella Turcica