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Serial muscle biopsies in a noncarcinomatous case of Lambert-Eaton myasthenic syndrome (LEMS) have shown progressive atrophy and loss of type 1 fibers, resulting in overwhelming type 2 predominance. A similar abnormality was found in a single biopsy from a second case of LEMS without associated carcinoma. Review of the literature suggests that type 2 fiber predominance has been observed in at least one other biopsied case. Interference with transmitter release caused by anti-voltage-gated calcium channel antibodies may deprive type 1 muscle fibers of the low frequency discharge necessary to maintain their metabolic properties.

Original publication

DOI

10.1002/mus.880140705

Type

Journal article

Journal

Muscle Nerve

Publication Date

07/1991

Volume

14

Pages

625 - 632

Keywords

Adolescent, Adult, Biopsy, Electrodiagnosis, Electrophysiology, Evoked Potentials, Humans, Lambert-Eaton Myasthenic Syndrome, Male, Muscle Contraction, Muscles