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The bioenergetic state of 15 human tumours was examined with phosphorus-31 magnetic resonance spectroscopy. A striking diversity in metabolic patterns was observed, and significant differences from normal tissue were seen in all cases. A common feature was an elevation of intracellular pH, which may be related to an increase in Na+/H+ exchange during cell activation. It is unlikely that the patterns observed directly correlate with malignancy, but characterisation of the energetic state of a given tumour in a given physiological environment may help in the design and evaluation of interventions for that specific case.

Type

Journal article

Journal

Lancet

Publication Date

05/07/1986

Volume

2

Pages

8 - 11

Keywords

Adult, Aged, Brain Neoplasms, Breast Neoplasms, Female, Humans, Hydrogen-Ion Concentration, Kinetics, Liver Neoplasms, Magnetic Resonance Spectroscopy, Male, Middle Aged, Neoplasms, Phosphorus Radioisotopes, Spectrum Analysis