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We report a sibship in which the syndrome of congenital arthrogryposis occurred in two male and two female neonates, three of whom died. The mother was asymptomatic at the time of the first pregnancy and the subsequent development of muscle weakness was later confirmed to be due to myasthenia gravis. The literature on this association is briefly reviewed and the extremely high risk of recurrence of this complication in subsequent pregnancies is addressed.

Type

Journal article

Journal

Neuromuscul Disord

Publication Date

01/1995

Volume

5

Pages

59 - 65

Keywords

Adult, Arthrogryposis, Elbow, Family, Female, Humans, Infant, Infant, Newborn, Knee, Male, Myasthenia Gravis, Neuromuscular Junction, Pregnancy, Pregnancy Complications, Recurrence, Sex Distribution