Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings.

This study has measured the longitudinal and transverse (T2* relaxivity curves for ProHance (Gadoteridol), Vasovist (Gadofosveset) and deoxyhemoglobin at 1.5, 3.0, and 7.0 Tesla. The plots of R(1) versus both contrast agent and deoxyhemoglobin concentration were linear. The plots of R2* versus deoxyhemoglobin concentration showed a quadratic dependence. R2* versus contrast agent concentration showed a parabolic dependence with a minimum occurring at contrast agent concentrations of approximately 1.5 mM, corresponding to an accessible concentration in vivo. Monte Carlo simulations were performed to support the hypothesis that the minimum results from the susceptibility of the red blood cells being matched to the susceptibility of the plasma. Relaxivity values (s(-1)mM(-1)) for R2* and R1 for all agents and all three field strengths are given.

Original publication

DOI

10.1002/mrm.21792

Type

Journal article

Journal

Magn Reson Med

Publication Date

12/2008

Volume

60

Pages

1313 - 1320

Keywords

Blood Chemical Analysis, Contrast Media, Dose-Response Relationship, Radiation, Gadolinium, Hemoglobin, Sickle, Heterocyclic Compounds, Humans, Magnetics, Organometallic Compounds, Oxygen, Radiation Dosage