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Flu-like symptoms and injection site reactions are adverse effects of treatment with interferon beta-1b in patients with MS. We compared gradual dose escalation, ibuprofen treatment, or their combination in an open-label study. The combination reduced the incidence of flu-like symptoms to rates comparable with the placebo group in the pivotal trial but increased the frequency of injection site reactions, albeit modestly and transiently.

Type

Journal article

Journal

Neurology

Publication Date

10/06/1999

Volume

52

Pages

1893 - 1895

Keywords

Adolescent, Adult, Humans, Ibuprofen, Interferon beta-1a, Interferon beta-1b, Interferon-beta, Middle Aged, Multiple Sclerosis