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Multiple sclerosis (MS) is now thought to be a complex trait determined by genetic and non-genetic (environmental) factors. The study group, identified from the Canadian Collaborative Project on Genetic Susceptibility to MS, consisted of 1,083 MS index cases, 2,166 of their parents and 3,112 of their sibs. The results, together with those of a previous study on an independent data set, suggest that gender, age of MS onset and having one parent with MS may individually and interactively alter sib risks for MS. These data are important for genetic counselling and for molecular genetic (genome screens, candidate gene analyses) studies.

Type

Journal article

Journal

Clin Genet

Publication Date

12/2000

Volume

58

Pages

431 - 435

Keywords

Adolescent, Adult, Age of Onset, Aged, Family Health, Female, Humans, Male, Middle Aged, Multiple Sclerosis, Risk Factors, Sex Factors