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The natural history of chronic diseases is generally poorly understood. Multiple sclerosis is one of the best-studied diseases and we outline here some of the information obtained from 25,000 patient-years of observation. This population-based cohort received almost no treatment and certainly none known to alter the long-term natural course of the illness. There is a possibility that such data will prove useful in new generation clinical trials which are observational in nature.


Journal article


Neurol Sci

Publication Date





S815 - S817


Cohort Studies, Disability Evaluation, Follow-Up Studies, Humans, London, Multiple Sclerosis, Recurrence