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Using population-based data, the authors identified 24 MS index cases whose parents were related. Twenty-two had 67 sibs of whom 6 also had MS, yielding a recurrence risk of approximately 9%, significantly higher than for sibs of MS index cases from nonconsanguineous parents. These findings support the concept that multiple interacting genes increase the risk of MS.

Type

Journal article

Journal

Neurology

Publication Date

27/03/2001

Volume

56

Pages

784 - 785

Keywords

Consanguinity, Humans, Multiple Sclerosis, Nuclear Family, Recurrence, Risk Factors