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Hypokalemic periodic paralysis (HOKPP) is an autosomal dominant neuromuscular disorder characterized by flaccid paralysis accompanied by lowered serum potassium levels. We have tested polymorphic markers linked to the adult skeletal muscle sodium channel (SCN4A) locus at 17q23-q25, the T-cell receptor beta (TCRB) locus at 7q35, and the H-Ras cellular proton-cogene locus (HRAS) at 11p15.5 for linkage with the affected phenotype in a single multigenerational pedigree. No evidence for genetic linkage to HOKPP was found at any of the candidate loci.

Type

Journal article

Journal

Genomics

Publication Date

10/1992

Volume

14

Pages

493 - 494

Keywords

Chromosome Mapping, Chromosomes, Human, Pair 17, Chromosomes, Human, Pair 7, Genetic Linkage, Humans, Hypokalemia, Muscles, Paralyses, Familial Periodic, Phenotype, Polymorphism, Genetic, Receptors, Antigen, T-Cell, alpha-beta, Sodium Channels