Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings.

Primary lateral sclerosis (PLS) may be distinguished on the basis of clinical and pathological features from amyotrophic lateral sclerosis (ALS). The former is featured by a much longer clinical course, exclusively upper motor neuron findings, losses of precentral pyramidal neurons, and preservation of anterior horn cells. Electrophysiological studies of 7 PLS cases have shown normal peripheral motor conduction, absent or very delayed motor-evoked potentials, the occasional late development of denervation activity in distal muscles, and normal somatosensory-evoked potentials.

Original publication

DOI

10.1002/mus.880150515

Type

Journal article

Journal

Muscle Nerve

Publication Date

05/1992

Volume

15

Pages

626 - 629

Keywords

Aged, Amyotrophic Lateral Sclerosis, Diagnosis, Differential, Electromyography, Evoked Potentials, Evoked Potentials, Somatosensory, Humans, Middle Aged, Motor Neurons, Muscles, Neural Conduction