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Microchimerism, the persistence of foreign cells thought to derive from previous pregnancies, has been associated with autoimmune diseases. A maternal parent-of-origin effect in MS remains unexplained. We tested for microchimerism in monozygotic and dizygotic twin-pairs with MS. Microchimerism was associated with MS in affected females from monozygotic concordant pairs when compared to both affected (p=0.020) and unaffected (p=0.025) females in monozygotic discordant pairs. Microchimerism was increased in affected females of dizygotic discordant pairs (p=0.059). The rate of microchimerism was significantly higher in affected twins than in unaffected co-twins (p=0.0059). These observations show an association in twins between the presence of microchimerism and having MS.

Original publication

DOI

10.1016/j.jneuroim.2006.06.011

Type

Journal article

Journal

J Neuroimmunol

Publication Date

10/2006

Volume

179

Pages

145 - 151

Keywords

Canada, Chimerism, Diseases in Twins, Female, Humans, Male, Multiple Sclerosis, Pedigree, Polymerase Chain Reaction, Twins, Dizygotic, Twins, Monozygotic