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BACKGROUND: A month-of-birth (MOB) effect has been shown in multiple sclerosis (MS). METHODS: Our chi(2) analyses looked at whether this MOB effect differed by MS phenotype ("bout onset," "primary progressive"). RESULTS: The MOB effect was derived from "bout onset" MS patients (May/November ratio = 1.43; chi(2) = 17.32, df = 1, p = 0.000032). CONCLUSIONS: An unspecified environmental effect in early development can influence both multiple sclerosis susceptibility and phenotype.

Original publication

DOI

10.1212/01.wnl.0000265053.22905.64

Type

Journal article

Journal

Neurology

Publication Date

03/07/2007

Volume

69

Pages

60 - 62

Keywords

Canada, Disease Susceptibility, Female, Humans, Male, Multiple Sclerosis, Chronic Progressive, Multiple Sclerosis, Relapsing-Remitting, Parturition, Phenotype, Pregnancy, Prenatal Exposure Delayed Effects, Seasons, Sex Ratio, Siblings