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To assess the survival impact of the presence of P/Q-type calcium channel antibodies in patients with small cell lung carcinoma (SCLC), we examined the frequency of the antibodies and Lambert-Eaton myasthenic syndrome (LEMS) in 148 consecutive patients with SCLC, and in 30 patients with paraneoplastic cerebellar degeneration and SCLC, and studied their relation with survival. In both series, only patients with LEMS had a remarkably long survival, whereas presence of the antibodies without LEMS did not result in a better prognosis.

Original publication

DOI

10.1016/j.jneuroim.2005.04.001

Type

Journal article

Journal

J Neuroimmunol

Publication Date

07/2005

Volume

164

Pages

161 - 165

Keywords

Adult, Aged, Autoantibodies, Blotting, Western, Calcium Channels, N-Type, Carcinoma, Small Cell, Cohort Studies, Female, Follow-Up Studies, Humans, Immunoprecipitation, Lambert-Eaton Myasthenic Syndrome, Male, Middle Aged, Radioimmunoassay, Retrospective Studies, Spain