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A population-based study of pairs of relatives (siblings, second- and third-degree) concordant for multiple sclerosis did not show an excess of like-sexed pairs. In addition, data on human lymphocyte antigen typing for sibling pairs concordant for multiple sclerosis did not find an increase in haplotype sharing for like-sexed pairs. These data do not support the notion that sex-related factors influence multiple-sclerosis susceptibility in families.

Type

Journal article

Journal

Arch Neurol

Publication Date

06/1991

Volume

48

Pages

586 - 588

Keywords

Disease Susceptibility, Family, Female, Humans, Male, Multiple Sclerosis, Sex