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<jats:title>ABSTRACT:</jats:title><jats:p>We report the clinical and laboratory findings of six Canadian patients with progressive myelopathy associated with HTLV-1 infection. The diagnosis was suspected on clinical grounds and supported by serological studies and positive gene amplification. Only five had emigrated from an area endemic for HTLV-1 infection. Tropical spastic paraparesis should be considered in all patients with myelopathy, even those without standard serological markers of HTLV-1 infection. The pathogenesis of this condition and the serological and molecular biological means by which this diagnosis can be made are reviewed.</jats:p>

Original publication

DOI

10.1017/s0317167100029176

Type

Journal article

Journal

Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques

Publisher

Cambridge University Press (CUP)

Publication Date

08/1989

Volume

16

Pages

330 - 335