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Studies which have attempted to define the outcome of multiple sclerosis (MS) have methodologic difficulties arising from patient referral biases and the length of follow-up required, which make prospective studies of an inception cohort unrealistic. Means to improve the validity of retrospective natural history studies are suggested. Results of existing series are summarized and compared. Survival is only rarely shortened by MS, but disability to the point of requiring aids for ambulation occurs in 30-70% of patients by 15 years from onset of symptoms. Disagreement as to the percentage of patients who are ultimately bedridden by MS likely arises in large part due to differences in patient ascertainment and follow-up. The need to develop early clinical markers for the patient at high risk for rapid development of major disability is stressed.

Type

Journal article

Journal

Can J Neurol Sci

Publication Date

08/1987

Volume

14

Pages

255 - 261

Keywords

Actuarial Analysis, Cross-Sectional Studies, Disability Evaluation, Epidemiologic Methods, Humans, Longitudinal Studies, Multiple Sclerosis, Prognosis, Prospective Studies, Retrospective Studies