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In a 27-member family, 8 individuals had mitral valve prolapse (MVP) by echocardiography. Four of them suffered a total of eight cerebral ischemic events in the first four decades of life. In none of these patients could risk factors for stroke, other than MVP, be found. Stroke did not occur in individuals free of MVP. This report draws attention to a previously unrecognized cause of familial stroke which strengthens the relationship between MVP and premature stroke.

Original publication

DOI

10.1002/ana.410070207

Type

Journal article

Journal

Ann Neurol

Publication Date

02/1980

Volume

7

Pages

130 - 134

Keywords

Adult, Aspirin, Female, HLA Antigens, Humans, Intracranial Embolism and Thrombosis, Male, Middle Aged, Mitral Valve Prolapse, Pedigree, Syndrome