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The objective of this study was to investigate genes involved in the metabolism and function of vitamin D as candidate genes for genetic susceptibility to MS. Restriction fragment length polymorphisms and highly polymorphic microsatellite markers within or very close to the 1,25(OH) 2 D 3 receptor (VDR) [12q14], the vitamin D binding protein (DBP) [4q12] , and the 25(OH)D 3 1α-hydroxylase [12q13] loci were analyzed for linkage or association with MS. We found no evidence for linkage or association of these candidate genes with MS in the Canadian population.

Type

Journal article

Journal

Neurology

Publication Date

08/02/2000

Volume

54

Pages

729 - 732