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A novel X-linked gene, DXS8237E, was isolated from human fetal brain cDNA, and its 3' end was mapped to within 20 kb upstream of UBE1 in Xp11.23. A 1.3-kb cDNA for DXS8237E detects homologous sequences in other mammals and a 3-kb mRNA that is widely expressed in human cell lines and mouse tissues. Sequence analysis indicated that the 1.3-kb cDNA contains the 3' end of the DXS8237E gene, but the sequence shows no significant homology to known genes. DXS8237E was shown to be subject to X inactivation in five somatic cell hybrids that contain an inactive human X chromosome but no active homologue. Since UBE1 escapes X inactivation, DXS8237E and UBE1 are the closest mapped genes with discordant X inactivation profiles. Sequences in the vicinity of these two genes may be important determinants of X inactivation status.

Original publication

DOI

10.1006/geno.1996.0022

Type

Journal article

Journal

Genomics

Publication Date

01/01/1996

Volume

31

Pages

135 - 138

Keywords

Animals, Base Sequence, Chromosome Mapping, Cricetinae, DNA Primers, DNA, Complementary, Dosage Compensation, Genetic, Female, Gene Expression, Genetic Linkage, Genetic Markers, Humans, Hybrid Cells, Ligases, Mice, Molecular Sequence Data, RNA, Messenger, Ubiquitin-Protein Ligases, X Chromosome