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Functional Magnetic Resonance imaging studies analyse sequences of brain volumes whose intensity changes predominantly reflect blood oxygenation level dependent (BOLD) effects. The most comprehensive signal model to date of the BOLD effect is formulated as a continuous-time system of nonlinear stochastic differential equations. In this paper we present a particle filtering method for the analysis of the BOLD system, and demonstrate it to be both accurate and robust in estimating the hidden physiological states including cerebral blood flow, cerebral blood volume, total deoxyhemoglobin content, and the flow inducing signal, from functional imaging data.

Type

Conference paper

Publication Date

2006

Volume

9

Pages

292 - 299

Keywords

Algorithms, Brain, Brain Mapping, Computer Simulation, Humans, Image Enhancement, Image Interpretation, Computer-Assisted, Magnetic Resonance Imaging, Models, Neurological, Oxygen, Oxygen Consumption, Reproducibility of Results, Sensitivity and Specificity