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The discovery of a novel series of 8-azabicyclo[3.2.1]octan-3-yl)-3-(4-chlorophenyl) propanamide antagonists of the vasopressin V(1A) receptor is disclosed. Compounds 47 and 48 were found to be high affinity, selective vasopressin V(1A) antagonists.

Original publication

DOI

10.1016/j.bmcl.2011.02.096

Type

Journal article

Journal

Bioorg Med Chem Lett

Publication Date

15/05/2011

Volume

21

Pages

3163 - 3167

Keywords

Amides, Antidiuretic Hormone Receptor Antagonists, Aza Compounds, Cells, Cultured, Cyclization, Drug Discovery, Humans, Liver, Molecular Structure, Protein Binding