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The macaque brain serves as a model for the human brain, but its suitability is challenged by unique human features, including connectivity reconfigurations, which emerged during primate evolution. We perform a quantitative comparative analysis of the whole brain macroscale structural connectivity of the two species. Our findings suggest that the human and macaque brain as a whole are similarly wired. A region-wise analysis reveals many interspecies similarities of connectivity patterns, but also lack thereof, primarily involving cingulate regions. We unravel a common structural backbone in both species involving a highly overlapping set of regions. This structural backbone, important for mediating information across the brain, seems to constitute a feature of the primate brain persevering evolution. Our findings illustrate novel evolutionary aspects at the macroscale connectivity level and offer a quantitative translational bridge between macaque and human research.

Original publication

DOI

10.1371/journal.pcbi.1003529

Type

Journal article

Journal

PLoS Comput Biol

Publication Date

03/2014

Volume

10

Keywords

Adult, Animals, Anisotropy, Brain, Brain Mapping, Cluster Analysis, Connectome, Diffusion, Diffusion Magnetic Resonance Imaging, Female, Humans, Macaca, Male, Nerve Net, Neural Pathways, Species Specificity