Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings.

A previous study showed that, in carriers of the apolipoprotein E (APOE) genotype ε3/ε3 or ε3/ε4, the presence of a very long (VL) polyT repeat allele in "translocase of outer mitochondrial membrane 40" (TOMM40) was less frequent in patients with sporadic inclusion body myositis (sIBM) compared with controls and associated with a later age of sIBM symptom onset, suggesting a protective effect of this haplotype. To further investigate the influence of these genetic factors in sIBM, we analyzed a large sIBM cohort of 158 cases as part of an International sIBM Genetics Study. No significant association was found between APOE or TOMM40 genotypes and the risk of developing sIBM. We found that the presence of at least 1 VL polyT repeat allele in TOMM40 was significantly associated with about 4 years later onset of sIBM symptoms. The age of onset was delayed by 5 years when the patients were also carriers of the APOE genotype ε3/ε3. In addition, males were likely to have a later age of onset than females. Therefore, the TOMM40 VL polyT repeat, although not influencing disease susceptibility, has a disease-modifying effect on sIBM, which can be enhanced by the APOE genotype ε3/ε3.

Original publication

DOI

10.1016/j.neurobiolaging.2014.12.039

Type

Journal article

Journal

Neurobiol Aging

Publication Date

04/2015

Volume

36

Pages

1766.e1 - 1766.e3

Keywords

APOE, Age of onset, Sporadic inclusion body myositis, TOMM40, sIBM, Age of Onset, Aged, Alleles, Apolipoproteins E, Cohort Studies, Female, Genetic Association Studies, Genotype, Heterozygote, Humans, Introns, Male, Membrane Transport Proteins, Middle Aged, Myositis, Inclusion Body, Polymorphism, Genetic, Sex Factors