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Three cases of androgen-dependent disease in females with myotonic dystrophy are described. Serum androgens in individuals affected by myotonic dystrophy are known to be lower on average than in normal controls. Despite this these three females developed diseases that are androgen dependent, including acne, hidradenitis suppurativa, androgenetic alopecia and keratosis pilaris. These cases support the hypothesis that the peripheral response to androgens rather than absolute circulating levels of androgens is important in androgen-dependent conditions.

Type

Journal article

Journal

J Eur Acad Dermatol Venereol

Publication Date

01/2003

Volume

17

Pages

56 - 58

Keywords

Acne Vulgaris, Adult, Alopecia, Androgens, Female, Hidradenitis Suppurativa, Humans, Keratosis, Myotonic Dystrophy