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Copyright © 2014 Wolters Kluwer Health, Inc. All rights reserved. A 28-month-old infant presented with fever, vomiting and encephalopathy. Magnetic resonance imaging findings and family history confirmed a diagnosis of recurrent familial acute necrotizing encephalopathy (ANE1). We believe that this is the first description implicating the H1N1 viral strain as a trigger and the second report of a T653I mutation in the RANBP2 gene described in relation to ANE1.

Original publication




Journal article


Pediatric Infectious Disease Journal

Publication Date





318 - 320