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Reduced speed of cerebral information processing is a cognitive deficit associated with schizophrenia. Normal information processing speed (PS) requires intact white matter (WM) physiology to support information transfer. In a cohort of 107 subjects (47/60 patients/controls), we demonstrate that PS deficits in schizophrenia patients are explained by reduced WM integrity, which is measured using diffusion tensor imaging, mediated by the mismatch in WM/gray matter blood perfusion, and measured using arterial spin labeling. Our findings are specific to PS, and testing this hypothesis for patient-control differences in working memory produces no explanation. We demonstrate that PS deficits in schizophrenia can be explained by neurophysiological alterations in cerebral WM. Whether the disproportionately low WM integrity in schizophrenia is due to illness or secondary due to this disorder deserves further examination.

Original publication

DOI

10.1002/hbm.22878

Type

Journal article

Journal

Hum Brain Mapp

Publication Date

10/2015

Volume

36

Pages

3793 - 3804

Keywords

DTI-FA, acute change, attention, cognition, nicotine, processing speed, white matter, Adult, Algorithms, Cerebrovascular Circulation, Diffusion Tensor Imaging, Female, Gray Matter, Humans, Male, Memory, Short-Term, Middle Aged, Perfusion, Psychomotor Performance, Schizophrenia, Schizophrenic Psychology, Smoking, Spin Labels, White Matter