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Myelin is essential for rapid and accurate conduction of electrical impulses by axons in the central and peripheral nervous system (PNS). Myelin is formed in the early postnatal period, and developmental myelination in the PNS depends on axonal signals provided by Nrg1/ErbB receptors. In addition, Nrg1 is required for effective nerve repair and remyelination in adulthood. We discuss here similarities and differences in Nrg1/ErbB functions in developmental myelination and remyelination after nerve injury.

Original publication

DOI

10.1016/bs.ctdb.2015.11.009

Type

Journal article

Journal

Curr Top Dev Biol

Publication Date

2016

Volume

116

Pages

45 - 64

Keywords

Myelination, Nrg1, Peripheral nervous system, Remyelination, Animals, ErbB Receptors, Humans, Myelin Sheath, Nerve Regeneration, Neuregulin-1, Peripheral Nerve Injuries, Protein Biosynthesis, Schwann Cells, Signal Transduction