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It is recognized that neuropsychiatric conditions are overrepresented in amyotrophic lateral sclerosis (ALS) patient kindreds and psychiatric symptoms may precede the onset of motor symptoms. Using a hospital record linkage database, hospitalization with a diagnosis of schizophrenia, bipolar disorder, depression, or anxiety was significantly associated with a first diagnosis of ALS within the following year. This is likely to specifically reflect the clinicopathological overlap of ALS with frontotemporal dementia. A diagnosis of depression was significantly associated with a first record of ALS ≥5 years later, in keeping with growing evidence for major depressive disorder as an early marker of cerebral neurodegeneration. Ann Neurol 2016;80:935-938.

Original publication

DOI

10.1002/ana.24801

Type

Journal article

Journal

Ann Neurol

Publication Date

12/2016

Volume

80

Pages

935 - 938

Keywords

Amyotrophic Lateral Sclerosis, Case-Control Studies, Comorbidity, Databases, Factual, England, Female, Humans, Male, Mental Disorders, Time Factors