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Retinal ganglion cells react to changes in visual contrast by adjusting their sensitivity and temporal filtering characteristics. This contrast adaptation has primarily been studied under spatially homogeneous stimulation. Yet, ganglion cell receptive fields are often characterized by spatial subfields, providing a substrate for nonlinear spatial processing. This raises the question whether contrast adaptation follows a similar subfield structure or whether it occurs globally over the receptive field even for local stimulation. We therefore recorded ganglion cell activity in isolated salamander retinas while locally changing visual contrast. Ganglion cells showed primarily global adaptation characteristics, with notable exceptions in certain aspects of temporal filtering. Surprisingly, some changes in filtering were most pronounced for locations where contrast did not change. This seemingly paradoxical effect can be explained by a simple computational model, which emphasizes the importance of local nonlinearities in the retina and suggests a reevaluation of previously reported local contrast adaptation.

Original publication

DOI

10.1016/j.neuron.2012.12.030

Type

Journal article

Journal

Neuron

Publication Date

06/03/2013

Volume

77

Pages

915 - 928

Keywords

Adaptation, Physiological, Ambystoma mexicanum, Animals, Computer Simulation, Contrast Sensitivity, Electrophysiological Phenomena, Extracellular Space, Models, Neurological, Nonlinear Dynamics, Photic Stimulation, Retinal Ganglion Cells, Visual Fields