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Hybridization studies of mRNA link genetic with neurochemical and neuropathological approaches to Alzheimer's disease (AD). Here we review the distribution and abundance of amyloid precursor protein mRNAs in normal and AD-afflicted brains. The expression of apolipoprotein E and presenilin mRNAs are also discussed.

Type

Journal article

Journal

Neurodegeneration

Publication Date

12/1996

Volume

5

Pages

409 - 415

Keywords

Alzheimer Disease, Amyloid beta-Protein Precursor, Animals, Apolipoproteins E, Humans, Membrane Proteins, Presenilin-1, Presenilin-2, RNA, Messenger, Tissue Distribution